Brain Molecular Markers (Brain (V9 2023+))
- David Rust
Organization | Field Name | ID# | ID Name | Required |
|---|---|---|---|---|
KCR | Brain Molecular Markers | 34013 | BrainMolecularMarker | yes |
SEER | Brain Molecular Markers | brainMolecularMarkers | yes |
Note 1 Physician Statement
Physician statement of histologic subtype can be used to code this data item when no other information is available.
Note 2 Data item history
This data item was introduced in 2018 and applied to the following ICD-O-3 histology codes 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3
These are codes 01-09 and are applicable for cases diagnosed 2018+ and are in ICD-O-3 order
In 2022, the 5th edition of the CNS WHO Blue Book was released and the following histologies were added 9385/3, 9396/3, 9421/1, 9430/3, 9500/3
These are codes 10-23 and are applicable for cases diagnosed 2024+ and are in ICD-O-3 order
Code | ICD-O-3 Code | ICD-O-Description |
|---|---|---|
01 | 9400/3 | Astrocytoma, IDH-mutant, grade 2 |
02 | 9400/3 | Diffuse astrocytoma, IDH-wildtype |
03 | 9401/3 | Astrocytoma, IDH-mutant, grade 3 |
04 | 9401/3 | Anaplastic astrocytoma, IDH-wildtype |
05 | 9440/3 | Glioblastoma, IDH-wildtype |
06 | 9450/3 | Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted |
07 | 9451/3 | Oligodendroglioma, IDH-mutant and 1p/19q co-deleted, grade 3 |
08 | 9471/3 | Medulloblastoma, SHH-activated and TP53-wildtype |
09 | 9478/3 | Embryonal tumor with multilayered rosettes, C19MC-altered |
10 | 9385/3 | Diffuse hemispheric glioma, H3-34 mutant |
11 | 9385/3 | Diffuse midline glioma, H3 K27-altered |
12 | 9385/3 | Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype |
13 | 9385/3 | Infant-type hemispheric glioma |
14 | 9396/3 | Posterior fossa group A (PFA) ependymoma |
15 | 9396/3 | Posterior fossa group B (PFB) ependymoma |
16 | 9396/3 | Spinal ependymoma, MYCN-amplified |
17 | 9396/3 | Supratentorial ependymoma, YAP1 fusion-positive |
18 | 9396/3 | Supratentorial ependymoma, ZFTA fusion-positive |
19 | 9421/1 | Diffuse astrocytoma, MYB- or MYBL1-altered |
20 | 9421/1 | Diffuse low-grade glioma, MAPK pathway-altered |
21 | 9430/3 | Astroblastoma, MN1-altered |
22 | 9500/3 | CNS neuroblastoma, FOXR2-activated |
23 | 9500/3 | CNS tumor BCOR internal tandem duplication |
85 | NA | Not applicable: Histology not 9385/3, 9396/3, 9400/3, 9401/3, 9421/1, 9430/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3, 9421/1, 9430/3, 9500/3 |
86 | NA | *Benign or borderline tumor |
87 | NA | Test ordered, results not in chart |
88 | NA | Not applicable: Information not collected for this case |
99 | NA | Not documented in medical record |